Press Release
XBiotech Announces Completion and Positive Interim Findings for Initial Cohort in Bermekimab Pilot Study in Atopic Dermatitis
The Study Chair, Dr.
Bermekimab treatment was associated with the following statistically significant outcomes for assessment of atopic dermatitis severity and response:
- Eczema Area and Severity Index score (EASI) improved by at least 50% for one third of the patients from baseline to week 4 [p=0.02, Wilcoxon Signed-Rank Test (WSRT)].
- Dermatology Life Quality Index (DLQI), a questionnaire used to measure the impact of skin disease on the quality of life, showed a mean improvement of 57% (four out of nine patients showing at least a 75% improvement from baseline to week 4 of study, p=0.004, WSRT).
- The SCORAD, a clinical tool for assessing extent and intensity of atopic dermatitis, showed a mean improvement of 25% for the cohort after 4 weeks.
- The Pruritus Numerical Rating Scale (NRS), a patient-reported measure to assess itch intensity, decreased by more than 50% in one third of patients between baseline and Week 4 (p=0.04, WSRT).
- The Patient Oriented Eczema Measure (POEM), used to assess atopic dermatitis severity from the patient’s perspective, showed that seven out of nine patients reported more than 33% improvement from baseline to week 4 (p=0.004, WSRT).
- The Hospital Anxiety and Depression Scale (HADS) was used to measure patient symptoms of anxiety and depression during the study. Anxiety scores were reduced by at least half in 44% of patients. In addition, two thirds of patients improved their depression scores by at least 66% (Anxiety and depression scores, p=0.0078 and p=0.03, respectively, WSRT).
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