MIKE CAVALIER PH.D.
As a Ph.D. level Protein Biochemist with Postdoctoral training and relevant biotech experience, Dr. Cavalier oversees all aspects of cGMP manufacturing for XBiotech's True Human™ monoclonal antibody platform utilizing single use methodologies. He is responsible for oversight of all manufacturing personnel and manages the day to day operations of production to ensure timely delivery of drug product to our clinical research groups that have met all quality and engineering specification requirements. Previously at XBiotech, Dr. Cavalier had a role as an R&D Senior Scientist focusing in the purification of both antigens and antibodies expressed from bacteria and mammalian cells. He also led initial protein characterization, protein analytical assay development, and epitope binning activities to support antibody discovery.
Before XBiotech, Dr. Cavalier was a Postdoctoral Fellow at the University of Maryland School of Medicine in Baltimore, MD. There, as a member of the Center of Biomolecular Therapeutics, he worked as a structural biologist using X-ray Crystallography and NMR to investigate the structure-activity relationships of small molecule inhibitors to the targeted protein-protein interactions. Dr. Cavalier earned his doctorate in biochemistry at Louisiana State University in Baton Rouge, LA. At LSU, he used X-ray crystallography to determine the underlying mechanisms of enzymatic catalysis and to progress a rational drug design program while gaining extensive hands-on experience at the synchrotron beam-line operation. Through his career Dr. Cavalier acquired a significant background in Protein Biochemistry, protein/antibody purification, and biophysics. He has instructed emerging scientists, managed laboratory staff, authored peer-reviewed publications and grant applications, and presented data to principal scientists at major collaborating institutions.