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XBiotech Announces Oral Presentation of Atopic Dermatitis Results for Bermekimab at 2019 EADV Congress in Madrid, Spain
A highlight of the data to be reported is the observation that after only 8 weeks of bermekimab therapy, three-fourths of patients achieved 75% improvement in their Eczema Area and Severity Index (EASI 75) scores, a key measure of disease severity in AD. The current standard of care and the only approved biological therapy for AD involves a 16 week treatment regimen, which clinical trials have shown to result in 44-51% of patients achieving 75% improvement in EASI score. Another key finding to be reported in the bermekimab study was a dramatic reduction in itch, which can be debilitating in eczema patients. An overall reduction of ≥4 points based on the Numerical Rating Scale for itch is considered clinically significant. Seventy-five percent of patients achieved ≥4 point reduction in 8 weeks.
Atopic dermatitis, commonly referred to as eczema, is characterized by chronic inflammation of the skin, which results in a breakdown of the skin barrier and leads to dry, thickened, scaly skin, redness, and itching, the latter which can be debilitating and result in significant sleep disturbances and loss of quality of life. There’s an estimated 18 million people with AD in
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XBiotech’s True Human™ antibodies are derived without modification from individuals who possess natural immunity to certain diseases. With discovery and clinical programs across multiple disease areas, XBiotech’s True Human antibodies have the potential to harness the body’s natural immunity to fight disease with increased safety, efficacy and tolerability.
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Source: XBiotech Inc.